喹啉酸
犬尿氨酸途径
犬尿氨酸
多发性硬化
巴比妥酸
医学
肌萎缩侧索硬化
小胶质细胞
神经科学
精神分裂症(面向对象编程)
神经认知
疾病
神经炎症
免疫学
精神科
炎症
谷氨酸受体
心理学
内科学
生物
色氨酸
认知
氨基酸
受体
生物化学
作者
Jens O. Watzlawik,Bharath Wootla,Moses Rodriguez
标识
DOI:10.2174/1381612822666151215095940
摘要
Accumulating evidence demonstrates involvement of tryptophan metabolites and in particular activation of the kynurenine pathway (KP) in neurocognitive disorders under CNS inflammatory conditions. The KP is involved in several brain-associated disorders including Parkinson’s disease, AIDS dementia, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, schizophrenia, and brain tumors. Our review is an attempt to address any relevant association between dysregulation of KP and multiple sclerosis (MS), an inflammatory CNS disorder that ultimately leads to demyelinated brain areas and severe neurological deficits. Modulation of KP is a new topic for the field of MS and warrants further research. The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients. Keywords: Demyelination, microglia, macrophages, kynurenine pathway, quinolinic acid, kynurenic acid.
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