波形蛋白
中间灯丝
调节器
细胞生物学
细胞骨架
生物
细胞粘附
癌细胞
肌动蛋白
中间丝蛋白
癌症
细胞
免疫学
免疫组织化学
遗传学
基因
作者
Henna Pehkonen,Pernilla von Nandelstadh,Piia-Riitta Karhemo,Tatiana Lepikhova,Reidar Grénman,Kaisa Lehti,Outi Monni
摘要
Abstract PPFIA1 is located at the 11q13 region, which is one of the most commonly amplified regions in several epithelial cancers including head and neck squamous cell carcinoma and breast carcinoma. Considering the location of PPFIA1 in this amplicon, we examined whether protein encoded by PPFIA1 , liprin-α1, possesses oncogenic properties in relevant carcinoma cell lines. Our results indicate that liprin-α1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells. In non-invasive cells liprin-α1 promotes expansive growth behavior with limited invasive capacity, whereas in invasive cells liprin-α1 has significant impact on mesenchymal cancer cell invasion in three-dimensional collagen. Current results identify liprin-α1 as a novel regulator of the tumor cell intermediate filaments with differential oncogenic properties in actively proliferating or motile cells.
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