Protective of radix codonopsis on hemodynamics and myocardial enzyme after myocardial ischemia reperfusion injury

Objective To study the protective of radix codonopsis on myocardial ischemia reperfusion(I/R) injury rabbits.Methods 30 rabbits were randomly divided into control,I/R and radix codonopsis groups(n=10).Rabbits were fed with standard diet.After giving medicine 10 minutes,myocardial I/R injury animal model was established by ligaturing left ventricular branch of coronary artery.Changes of enzyme and hemodynamics in myocardial I/R were observed.Results Rabbits in model group myocardial function of shrink went down,amount of malondialdehyde(MDA) was higher,activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),Na+,K+-ATP and Ca2+-ATP were lower,lactic dehydrogenase(LDH) and creatine kinase(CK) were released.Compared with model group,radix codonopsis could recover left ventricular systolic pressure(LVSP) and ±dp/dtmax,decrease left ventricular end-diastolic pressure(LVEDP),inhibit the increasing of MDA,LDH and CK,increase the activities of SOD,GSH-PX,Na+,K+-ATP and Ca2+-ATP.Conclusions Radix codonopsis can obviously protect myocardial I/R injury.