Synthesis,Characterization and PTP1B Inhibitory Activity of the Vanadium Complexes with Amino-acids

Two vanadium-amino acid-hydroxylamido complexes,(1) and K2Cl·H2O(2) were synthesized.Their structures and components were characterized by elemental analysis,IR spectrometry,UV-Vis spectrometry,thermal analysis and X-ray single crystal diffraction and their PTP1B inhibitory activities were also explored.Complexes 1 and 2 both crystallize in triclinic system with space group P1.The central vanadium and seven coordinated atoms form a distorted pentagonal bipyramidal.Two O atoms and three N atoms from hydroxylamine and amino-acids define an equatorial plane approximately perpendicular to V-O.The N of hydroxylamine is cis to N of amino-acids and the O of amino-acids is trans to V-O.Complex 2 displays a good inhibitory activity against PTP1B(inhibition rate is 90.51% at 20 μg/mL).