脂质体
体外
化学
胆固醇
三乙胺
毒品携带者
阿霉素
溴化物
胎牛血清
阳离子脂质体
药物输送
色谱法
药理学
生物化学
有机化学
医学
化疗
转染
内科学
基因
作者
Jing Wang,Shengyong Geng,Jin‐Ye Wang
标识
DOI:10.1109/embc.2013.6610450
摘要
The purpose of this study was to investigate the physical stability and drug release of two cholesterol derivatives (4-cholesterocarbonyl-4'-(N,N,N-triethylamine butyloxyl bromide, CTBBA, and 4-cholesterocarbonyl-4'-(N,N'-diethylamino-butyloxy, CDBA), when combined with doxorubicin (DOX)-loaded liposomes in vitro. CTBBA-liposome revealed a positive charge at a pH between 3 and 10, as indicated by the ζ-potential. DOX-encapsulated CTBBA-liposomes possessed better physical stability both in PBS and in fetal bovine serum (FBS) added to PBS.
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