Elevated plasma myoglobin level is closely associated with type 2 diabetic kidney disease

医学 肌红蛋白 内科学 肾功能 糖尿病 肾脏疾病 逻辑回归 血红蛋白 2型糖尿病 入射(几何) 接收机工作特性 2型糖尿病 心脏病学 胃肠病学 内分泌学 有机化学 化学 物理 光学
作者
Lin Yang,Yan Shen,Wenxiao Li,Bingbing Zha,Wenjun Xu,Heyuan Ding
出处
期刊:Journal of Diabetes [Wiley]
标识
DOI:10.1111/1753-0407.13508
摘要

Abstract Background Diabetic kidney disease (DKD) is the most frequent complication in patients with type 2 diabetes mellitus (T2DM). It causes a chronic and progressive decline in kidney function, and ultimately patients require renal replacement therapy. To date, an increasing number of clinical studies have been conducted to explore the potential and novel biomarkers, which can advance the diagnosis, estimate the prognosis, and optimize the therapeutic strategies at the early stage of DKD. In the current study, we sought to investigate the association of plasma myoglobin with DKD. Methods A total of 355 T2DM patients with DKD and 710 T2DM patients without DKD were enrolled in this study. Laboratory parameters including blood cell count, hemoglobin A1c, biochemical parameters, and plasma myoglobin were recorded. Patients were classified on admission according to the tertile of myoglobin and clinical parameters were compared between the groups. Pearson correlation analysis, linear regression, logistic regression, receiver operating characteristics (ROC) analysis, and spline regression were performed. Results Plasma myoglobin significantly increased in patients with DKD and was associated with renal function and inflammatory parameters. Plasma myoglobin was an independent risk factor for the development of DKD. The area under ROC curve of myoglobin was 0.831. Spline regression showed that there was a significant linear association between DKD incidence and a high level of plasma myoglobin when it exceeded 36.4 mg/mL. Conclusions This study shows that elevated plasma myoglobin level is closely associated with the development of kidney injury in patients with T2DM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
橘橙色发布了新的文献求助30
1秒前
3秒前
酸奶烤着吃完成签到,获得积分10
3秒前
4秒前
4秒前
4秒前
刘亚茹发布了新的文献求助10
4秒前
留胡子的霆完成签到,获得积分10
5秒前
可爱的函函应助魏少爷采纳,获得10
8秒前
端庄涟妖发布了新的文献求助10
8秒前
坦率的寻双完成签到,获得积分10
8秒前
stitchkk应助cllg采纳,获得10
10秒前
10秒前
黄百川完成签到 ,获得积分10
12秒前
14秒前
15秒前
Fengh发布了新的文献求助10
15秒前
炎魔之王拉格纳罗斯完成签到,获得积分10
16秒前
机智的白昼完成签到,获得积分20
18秒前
18秒前
19秒前
孙成成发布了新的文献求助10
19秒前
Rondab应助xx采纳,获得10
19秒前
量子星尘发布了新的文献求助10
20秒前
欣欣子发布了新的文献求助10
21秒前
七七发布了新的文献求助10
23秒前
予安发布了新的文献求助10
24秒前
29秒前
pluto应助光亮笑柳采纳,获得10
31秒前
小小吴完成签到,获得积分10
31秒前
无问西东发布了新的文献求助20
33秒前
dkyt发布了新的文献求助10
33秒前
大模型应助lgw采纳,获得10
33秒前
七七完成签到,获得积分10
35秒前
Hello应助信仰阳光快乐采纳,获得10
36秒前
38秒前
略略完成签到,获得积分10
41秒前
向风完成签到,获得积分10
42秒前
饱满南松发布了新的文献求助10
43秒前
聪明的云完成签到 ,获得积分10
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975543
求助须知:如何正确求助?哪些是违规求助? 3519971
关于积分的说明 11200248
捐赠科研通 3256311
什么是DOI,文献DOI怎么找? 1798213
邀请新用户注册赠送积分活动 877446
科研通“疑难数据库(出版商)”最低求助积分说明 806338