Elevated plasma myoglobin level is closely associated with type 2 diabetic kidney disease

医学 肌红蛋白 内科学 肾功能 糖尿病 肾脏疾病 逻辑回归 血红蛋白 2型糖尿病 入射(几何) 接收机工作特性 2型糖尿病 心脏病学 胃肠病学 内分泌学 有机化学 化学 物理 光学
作者
Lin Yang,Yan Shen,Wenxiao Li,Bingbing Zha,Wenjun Xu,Heyuan Ding
出处
期刊:Journal of Diabetes [Wiley]
标识
DOI:10.1111/1753-0407.13508
摘要

Abstract Background Diabetic kidney disease (DKD) is the most frequent complication in patients with type 2 diabetes mellitus (T2DM). It causes a chronic and progressive decline in kidney function, and ultimately patients require renal replacement therapy. To date, an increasing number of clinical studies have been conducted to explore the potential and novel biomarkers, which can advance the diagnosis, estimate the prognosis, and optimize the therapeutic strategies at the early stage of DKD. In the current study, we sought to investigate the association of plasma myoglobin with DKD. Methods A total of 355 T2DM patients with DKD and 710 T2DM patients without DKD were enrolled in this study. Laboratory parameters including blood cell count, hemoglobin A1c, biochemical parameters, and plasma myoglobin were recorded. Patients were classified on admission according to the tertile of myoglobin and clinical parameters were compared between the groups. Pearson correlation analysis, linear regression, logistic regression, receiver operating characteristics (ROC) analysis, and spline regression were performed. Results Plasma myoglobin significantly increased in patients with DKD and was associated with renal function and inflammatory parameters. Plasma myoglobin was an independent risk factor for the development of DKD. The area under ROC curve of myoglobin was 0.831. Spline regression showed that there was a significant linear association between DKD incidence and a high level of plasma myoglobin when it exceeded 36.4 mg/mL. Conclusions This study shows that elevated plasma myoglobin level is closely associated with the development of kidney injury in patients with T2DM.
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