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未折叠蛋白反应
胸腺基质淋巴细胞生成素
细胞生物学
呼吸上皮
基因敲除
细胞因子
生物
免疫学
医学
肺
内科学
细胞培养
遗传学
作者
Prabuddha S. Pathinayake,Alan Hsu,Kristy Nichol,Jay C. Horvat,Philip M. Hansbro,Peter Wark
出处
期刊：American Journal of Physiology-lung Cellular and Molecular Physiology
[American Physiological Society]
日期：2024-05-01
卷期号：326 (5): L618-L626
标识
DOI：10.1152/ajplung.00378.2023
摘要
TSLP is an epithelial-derived cytokine and a key regulator in the pathogenesis of severe uncontrolled asthma. We demonstrate a novel mechanism by which endoplasmic reticulum stress signaling upregulates airway epithelial TSLP mRNA expression via the PERK-CHOP signaling pathway and enhances TLR3-mediated TSLP protein secretion.
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