Choroid plexus volume is increased in mood disorders and associates with circulating inflammatory cytokines

脉络丛 脑脊液 重性抑郁障碍 病理生理学 情绪障碍 炎症 内科学 医学 促炎细胞因子 免疫系统 内分泌学 免疫学 中枢神经系统 扁桃形结构 精神科 焦虑
作者
B. Bravi,Elisa Melloni,Marco Paolini,Mariagrazia Palladini,F. Calesella,L. Servidio,Elena Agnoletto,Sara Poletti,Cristina Lorenzi,Cristina Colombo,Francesco Benedetti
出处
期刊:Brain Behavior and Immunity [Elsevier BV]
卷期号:116: 52-61 被引量:9
标识
DOI:10.1016/j.bbi.2023.11.036
摘要

Depressed patients exhibit altered levels of immune-inflammatory markers both in the peripheral blood and in the cerebrospinal fluid (CSF) and inflammatory processes have been widely implicated in the pathophysiology of mood disorders. The Choroid Plexus (ChP), located at the base of each of the four brain ventricles, regulates the exchange of substances between the blood and CSF and several evidence supported a key role for ChP as a neuro-immunological interface between the brain and circulating immune cells. Given the role of ChP as a regulatory gate between periphery, CSF spaces and the brain, we compared ChP volumes in patients with bipolar disorder (BP) or major depressive disorder (MDD) and healthy controls, exploring their association with history of illness and levels of circulating cytokines. Plasma levels of inflammatory markers and MRI scans were acquired for 73 MDD, 79 BD and 72 age- and sex-matched healthy controls (HC). Patients with either BD or MDD had higher ChP volumes than HC. With increasing age, the bilateral ChP volume was larger in patients, an effect driven by the duration of illness; while only minor effects were observed in HC. Right ChP volumes were proportional to higher levels of circulating cytokines in the clinical groups, including IFN-γ, IL-13 and IL-17. Specific effects in the two diagnostic groups were observed when considering the left ChP, with positive association with IL-1ra, IL-13, IL-17, and CCL3 in BD, and negative associations with IL-2, IL-4, IL-1ra, and IFN-γ in MDD. These results suggest that ChP could represent a reliable and easy-to-assess biomarker to evaluate the brain effects of inflammatory status in mood disorders, contributing to personalized diagnosis and tailored treatment strategies.
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