Copper-Assisted (Pseudo-)Halochalcogenation of Arynes

In this report, we describe the multicomponent coupling reaction between arynes, (pseudo)halides, and an electrophilic chalcogen species. Addition of a copper salt enabled smooth conversion by suppressing side reactions. A variety of different aryne precursors as well as seleno- and thiosulfonates were employed, yielding a broad spectrum of ortho-(pseudo)halogenated chalcogenides. This motif was subjected to different cross-coupling approaches, demonstrating the applicability of these compounds as building blocks for more complex structures.