Expression of group II metabotropic glutamate receptors in rat superior cervical ganglion

代谢型谷氨酸受体2 代谢型谷氨酸受体 颈上神经节 内科学 内分泌学 生物 受体 医学 谷氨酸受体
作者
Xixi Wei,Chenlu Zhao,Xinyun Jia,Baosheng Zhao,Yuzhen Liu
出处
期刊:Autonomic Neuroscience: Basic and Clinical [Elsevier]
卷期号:244: 103053-103053 被引量:1
标识
DOI:10.1016/j.autneu.2022.103053
摘要

Background The superior cervical ganglion (SCG) plays critical roles in the regulation of blood pressure and cardiac output. Metabotropic glutamate receptors (mGluRs) in the SCG are not clearly elucidated yet. Most studies on the expression and functions of mGluRs in the SCG focused on the cultured SCG neurons, and yet little information has been reported in the SCG tissue. Chronic intermittent hypoxia (CIH), one of the major clinical features of obstructive sleep apnea (OSA) patients, is a critical pathological cause of secondary hypertension in OSA patients, but its impact on the level of mGluRs in the SCG is unknown. Objective To explore the expression and localization of mGluR2/3 and the effect of CIH on mGluR2/3 level in rat SCG tissue. Methods RT-PCR and immunostaining were conducted to examine the mRNA and protein expression of mGluR2/3 in rat SCG. Immunofluorescence staining was conducted to examine the distribution of mGluR2/3. Rats were divided into control and CIH group which the rats were exposed to CIH for 6 weeks. Western blots were performed to examine the level of mGluR2/3 in rat SCG. Results mRNAs of mGluR2/3 expressed in rat SCG. mGluR2 distributed in principal neurons and small intensely fluorescent cells but not in satellite glial cells, nerve fibers, and vascular endothelial cells; mGluR3 was detected in nerve fibers rather than in the cells mentioned above. CIH exposure reduced the protein level of mGluR2/3 in rat SCG. Conclusion mGluR2/3 exists in rat SCG with diverse distribution patterns, and may be involved in CIH-induced hypertension.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
zzz完成签到 ,获得积分10
2秒前
体贴半仙发布了新的文献求助10
5秒前
研友_VZG7GZ应助衰神采纳,获得10
6秒前
vigor完成签到 ,获得积分10
6秒前
trojan621应助YMM采纳,获得10
6秒前
8秒前
11秒前
pikaka完成签到,获得积分10
11秒前
12秒前
善学以致用应助阿巴理采纳,获得10
16秒前
王讯完成签到,获得积分10
16秒前
qq781208654发布了新的文献求助10
17秒前
沉思、完成签到,获得积分10
18秒前
星河在眼里完成签到,获得积分10
19秒前
一墨发布了新的文献求助20
20秒前
iWatchTheMoon应助ashore采纳,获得10
20秒前
Ganlou完成签到 ,获得积分20
22秒前
23秒前
衰神完成签到,获得积分10
24秒前
田様应助qq781208654采纳,获得10
27秒前
衰神发布了新的文献求助10
28秒前
28秒前
赵立韶华完成签到,获得积分10
29秒前
30秒前
阿巴理完成签到,获得积分10
32秒前
winnie完成签到,获得积分10
35秒前
西西弗斯发布了新的文献求助10
35秒前
sea发布了新的文献求助10
37秒前
矮小的寒天完成签到,获得积分10
38秒前
zhangpeng完成签到,获得积分10
38秒前
yayaya应助volcanoes采纳,获得10
38秒前
40秒前
QSJ完成签到,获得积分10
40秒前
40秒前
ymym发布了新的文献求助10
40秒前
酷波er应助西西弗斯采纳,获得10
41秒前
Migue应助科研通管家采纳,获得10
41秒前
科研通AI2S应助科研通管家采纳,获得10
41秒前
wwz应助科研通管家采纳,获得20
41秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162896
求助须知:如何正确求助?哪些是违规求助? 2813938
关于积分的说明 7902359
捐赠科研通 2473525
什么是DOI,文献DOI怎么找? 1316888
科研通“疑难数据库(出版商)”最低求助积分说明 631545
版权声明 602187