下调和上调
富血小板血浆
血管生成
细胞
蛋白质组学
血小板
医学
生物
细胞生物学
免疫学
癌症研究
生物化学
基因
作者
Zhitong Jiang,Can Huang,Yukui Zhang,Xiangbin Zhu,Na Li,Yu Huang,Peihe Wang,Hui Shan,Yuxin Yin,Hong Wang,Lei Huang,Zhen Han,Kunfu Ouyang,Lu Sun
标识
DOI:10.1021/acs.jproteome.4c00030
摘要
As people age, their ability to resist injury and repair damage decreases significantly. Platelet-rich plasma (PRP) has demonstrated diverse therapeutic effects on tissue repair. However, the inconsistency of patient outcomes poses a challenge to the practical application of PRP in clinical practice. Furthermore, a comprehensive understanding of the specific impact of aging on PRP requires a systematic investigation. We derived PRP from 6 young volunteers and 6 elderly volunteers, respectively. Subsequently, 95% of high-abundance proteins were removed, followed by mass spectrometry analysis. Data are available via ProteomeXchange with the identifier PXD050061. We detected a total of 739 proteins and selected 311 proteins that showed significant differences, including 76 upregulated proteins in the young group and 235 upregulated proteins in the elderly group. Functional annotation and enrichment analysis unveiled upregulation of proteins associated with cell apoptosis, angiogenesis, and complement and coagulation cascades in the elderly. Conversely, IGF1 was found to be upregulated in the young group, potentially serving as the central source of enhanced cell proliferation ability. Our investigation not only provides insights into standardizing PRP preparation but also offers novel strategies for augmenting the functionality of aging cells or tissues.
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