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Obesity and dyslipidemia in early life: Impact on cardiometabolic risk

血脂异常 肥胖 医学 内科学 环境卫生 老年学
作者
Aleksandra Zeljković,Jelena Vekić,Aleksandra Stefanovic
出处
期刊:Metabolism-clinical and Experimental [Elsevier BV]
卷期号:156: 155919-155919 被引量:19
标识
DOI:10.1016/j.metabol.2024.155919
摘要

Abstract

Childhood obesity with its growing prevalence worldwide presents one of the most important health challenges nowadays. Multiple mechanisms are involved in the development of this condition, as well as in its associations with various cardiometabolic complications, such as insulin resistance, diabetes, metabolic dysfunction-associated steatotic liver disease and cardiovascular diseases. Recent findings suggest that childhood obesity and associated dyslipidemia at least partly originate from epigenetic modifications that take place in the earliest periods of life, namely prenatal and perinatal periods. Hence, alterations of maternal metabolism could be fundamentally responsible for fetal and neonatal metabolic programming and consequently, for metabolic health of offspring in later life. In this paper, we will review recent findings on the associations among intrauterine and early postnatal exposure to undesirable modulators of metabolism, development of childhood obesity and later cardiometabolic complications. Special attention will be given to maternal dyslipidemia as a driven force for undesirable epigenetic modulations in offspring. In addition, newly proposed lipid biomarkers of increased cardiometabolic risk in obese children and adolescents will be analyzed, with respect to their predictive potential and clinical applicability.
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