Obesity and dyslipidemia in early life: Impact on cardiometabolic risk

血脂异常 肥胖 医学 内科学 环境卫生 老年学
作者
Aleksandra Zeljković,Jelena Vekić,Aleksandra Stefanovic
出处
期刊:Metabolism-clinical and Experimental [Elsevier BV]
卷期号:156: 155919-155919 被引量:19
标识
DOI:10.1016/j.metabol.2024.155919
摘要

Abstract

Childhood obesity with its growing prevalence worldwide presents one of the most important health challenges nowadays. Multiple mechanisms are involved in the development of this condition, as well as in its associations with various cardiometabolic complications, such as insulin resistance, diabetes, metabolic dysfunction-associated steatotic liver disease and cardiovascular diseases. Recent findings suggest that childhood obesity and associated dyslipidemia at least partly originate from epigenetic modifications that take place in the earliest periods of life, namely prenatal and perinatal periods. Hence, alterations of maternal metabolism could be fundamentally responsible for fetal and neonatal metabolic programming and consequently, for metabolic health of offspring in later life. In this paper, we will review recent findings on the associations among intrauterine and early postnatal exposure to undesirable modulators of metabolism, development of childhood obesity and later cardiometabolic complications. Special attention will be given to maternal dyslipidemia as a driven force for undesirable epigenetic modulations in offspring. In addition, newly proposed lipid biomarkers of increased cardiometabolic risk in obese children and adolescents will be analyzed, with respect to their predictive potential and clinical applicability.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Zhang完成签到,获得积分10
2秒前
3秒前
3秒前
4秒前
5秒前
圆锥香蕉给ZEcholy的求助进行了留言
6秒前
jisujun发布了新的文献求助10
6秒前
李小宁发布了新的文献求助10
6秒前
9秒前
Stroeve发布了新的文献求助10
10秒前
欧阳月空完成签到,获得积分10
10秒前
10秒前
星辰大海应助李小宁采纳,获得10
11秒前
段一帆发布了新的文献求助10
11秒前
冷艳的姿发布了新的文献求助10
11秒前
12秒前
FIN应助小小采纳,获得30
12秒前
领导范儿应助su采纳,获得10
13秒前
Candy发布了新的文献求助10
13秒前
Rondab应助xiaosu采纳,获得10
14秒前
CodeCraft应助LJJ采纳,获得10
15秒前
15秒前
SYLH应助科研通管家采纳,获得20
16秒前
所所应助科研通管家采纳,获得10
16秒前
科研通AI5应助科研通管家采纳,获得10
16秒前
张金蝶完成签到,获得积分10
16秒前
搜集达人应助科研通管家采纳,获得10
17秒前
CAOHOU应助科研通管家采纳,获得10
17秒前
丘比特应助科研通管家采纳,获得10
17秒前
CAOHOU应助科研通管家采纳,获得10
17秒前
赘婿应助科研通管家采纳,获得10
17秒前
量子星尘发布了新的文献求助30
17秒前
SYLH应助科研通管家采纳,获得20
17秒前
17秒前
17秒前
17秒前
CAOHOU应助科研通管家采纳,获得10
17秒前
Lyuhng+1完成签到 ,获得积分10
18秒前
大个应助十九岁的时差采纳,获得10
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173