化学
脂肪肝
荧光
粘度
药品
疾病
病理
药理学
光学
医学
物理
量子力学
作者
Jing‐Jing Chao,Qin-Ting Liao,Ling Hu,Zhiqiang Wang,Zhen-Zhen Peng,Guojiang Mao,Fen Xu,Yongfei Li,Chunyan Li
出处
期刊:Talanta
[Elsevier]
日期:2024-05-11
卷期号:276: 126227-126227
被引量:1
标识
DOI:10.1016/j.talanta.2024.126227
摘要
Fatty liver disease affects at least 25 percent of the population worldwide and is a severe metabolic syndrome. Viscosity is closely related to fatty liver disease, so it is urgent to develop an effective tool for monitoring viscosity. Herein, a NIR fluorescent probe called MBC-V is developed for imaging viscosity, consisting of dimethylaniline and malonitrile-benzopyran. MBC-V is non-fluorescent in low viscosity solutions due to intramolecular rotation. In high viscosity solution, the intramolecular rotation of MBC-V is suppressed and the fluorescence is triggered. MBC-V has long emission wavelength at 720 nm and large Stokes shift about 160 nm. Moreover, MBC-V can detect changes in cell viscosity in fatty liver cells, and can image the therapeutic effects of drug in fatty liver cells. By taking advantage of NIR emission, MBC-V can be used as an imaging tool for fatty liver disease and a way to evaluate the therapeutic effect of drug for fatty liver disease.
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