A Miniaturized and Highly Sensitive “Windmill” Three-Channel Fluorescence Detector for Simultaneous Detection of Various Mycotoxins

探测器 化学 光电二极管 灵敏度(控制系统) 荧光 发光二极管 光学 噪音(视频) 分析化学(期刊) 光电子学 物理 色谱法 工程类 电子工程 人工智能 计算机科学 图像(数学)
作者
Chuanliang Wang,Sha Tao,Jiashan Lu,Yafeng Guan,Xuhui Geng
出处
期刊:Analytical Chemistry [American Chemical Society]
卷期号:96 (25): 10121-10126
标识
DOI:10.1021/acs.analchem.4c00311
摘要

A novel "windmill" three-channel light-emitting diode induced fluorescence detector (LED-IF) was proposed to maximize the excitation efficiency and fluorescence collection efficiency. Compared with the typical collinear arrangement, the fluorescence intensity of the three channels was increased by 7.85, 3.88, and 2.94 times, respectively. The compact shaping optical path was designed to obtain higher excitation efficiency and a lower background stray light effect caused by high divergence angle high-power ultraviolet (UV)-LEDs simultaneously, which increased the sensitivity of three channels by 4.6 to 5.7 times. It was found that using a photodiode (PD) with a flat window and a larger photosensitive surface can collect the Lambertian emission fluorescence in the flow cell more efficiently, increasing the signal-to-noise ratio of each channel 1.3 to 1.8 times. The limits of detection (LODs, 3 times peak–peak noise) of aflatoxin B2 (AFB2), ochratoxin (OTA), and zearalenone (ZEN) were 0.33, 1.80, and 28.2 ng/L, respectively. Finally, six mycotoxins were analyzed simultaneously by the detector coupling with HPLC. The results showed that the sensitivity of the detector was at the best level to date, which was better than that of the top commercial fluorescence detectors (FLDs). The developed detector has the advantages of having small volume, low cost, and long lifetime and being robust, which has wide application and market prospects.
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