PI3K/AKT/mTOR通路
蛋白激酶B
生物合成
细胞生物学
哺乳期
化学
乳腺
信号转导
生物
生物化学
基因
遗传学
癌症
怀孕
乳腺癌
作者
Jianbing Tan,B. K. Yang,Liang Qiu,Ruiying He,Zhangqing Wu,M. Ye,Linsen Zan,Wucai Yang
标识
DOI:10.1021/acs.jafc.4c02508
摘要
Milk fat synthesis has garnered significant attention due to its influence on the quality of milk. Recently, an increasing amount of proofs have elucidated that microRNAs (miRNAs) are important post-transcriptional factor involved in regulating gene expression and play a significant role in milk fat synthesis. MiR-200a was differentially expressed in the mammary gland tissue of dairy cows during different lactation periods, which indicated that miR-200a was a candidate miRNA involved in regulating milk fat synthesis. In our research, we investigated the potential function of miR-200a in regulating milk fat biosynthesis in bovine mammary epithelial cells (BMECs). We discovered that miR-200a inhibited cellular triacylglycerol (TAG) synthesis and suppressed lipid droplet formation; at the same time, miR-200a overexpression suppressed the mRNA and protein expression of milk fat metabolism-related genes, such as fatty acid synthase (
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