胆固醇
ABCA1
生物
髓鞘
脂筏
平衡
外周髓鞘蛋白22
疾病
细胞生物学
神经科学
中枢神经系统
运输机
内科学
遗传学
内分泌学
医学
基因
作者
Katherine M. Stefanski,Mason C. Wilkinson,Charles R. Sanders
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2024-07-09
摘要
Underexpression, overexpression, and point mutations in peripheral myelin protein 22 (PMP22) cause most cases of Charcot-Marie-Tooth disease (CMTD). While its exact functions remain unclear, PMP22 is clearly essential for formation and maintenance of healthy myelin in the peripheral nervous system. This review explores emerging evidence for roles of PMP22 in cholesterol homeostasis. First, we highlight dysregulation of lipid metabolism in PMP22-based forms of CMTD and recently-discovered interactions between PMP22 and cholesterol biosynthesis machinery. We then examine data that demonstrates PMP22 and cholesterol co-traffic in cells and co-localize in lipid rafts, including how disease-causing PMP22 mutations result in aberrations in cholesterol localization. Finally, we examine roles for interactions between PMP22 and ABCA1 in cholesterol efflux. Together, this emerging body of evidence suggests that PMP22 plays a role in facilitating enhanced cholesterol synthesis and trafficking necessary for production and maintenance of healthy myelin.
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