高胰岛素血症
脂肪生成
疾病
脂肪肝
医学
脂肪变性
肥胖
代谢综合征
环境卫生
内科学
胰岛素抵抗
内分泌学
脂质代谢
作者
Helaina Huneault,Ana Ramirez Tovar,Cristian Sanchez-Torres,Jean A. Welsh,Miriam B. Vos
标识
DOI:10.1097/hc9.0000000000000297
摘要
NAFLD, or metabolic dysfunction–associated steatotic liver disease, has increased in prevalence hand in hand with the rise in obesity and increased free sugars in the food supply. The causes of NAFLD are genetic in origin combined with environmental drivers of the disease phenotype. Dietary intake of added sugars has been shown to have a major role in the phenotypic onset and progression of the disease. Simple sugars are key drivers of steatosis, likely through fueling de novo lipogenesis, the conversion of excess carbohydrates into fatty acids, but also appear to upregulate lipogenic metabolism and trigger hyperinsulinemia, another driver. NAFLD carries a clinical burden as it is associated with obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Patient quality of life is also impacted, and there is an enormous economic burden due to healthcare use, which is likely to increase in the coming years. This review aims to discuss the role of dietary sugar in NAFLD pathogenesis, the health and economic burden, and the promising potential of sugar reduction to improve health outcomes for patients with this chronic liver disease.
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