止血
医学
钙
止血剂
钠
药理学
海藻酸钙
麻醉
内科学
化学
有机化学
作者
Yuto Kubo,Masahiro Satoh,Sayaka Suzuki,Takahiro Yoshihara,Ryuichi Nishida,Junji Yamamoto,Kotaro Yamashita,Takuro Saito,Yuto Kubo,Tomoki Makino,Kazuyoshi Yamamoto,Tsuyoshi Takahashi,Yukinori Kurokawa,Hidetoshi Eguchi,Yuichiro� Doki,Kiyokazu Nakajima
出处
期刊:Surgery
[Elsevier]
日期:2023-12-01
卷期号:174 (6): 1445-1452
被引量:1
标识
DOI:10.1016/j.surg.2023.08.019
摘要
Abstract
Background
The demand for nonbiological hemostatic materials has increased in surgical practice; however, few have sufficient hemostatic efficacy. This study investigated whether optimizing the composition of sodium calcium alginate, which forms a stable gel, improves hemostatic efficacy. Methods
The sodium calcium alginate was changed for each composition, including powder size, calcium substitution rate, molecular weight, and mannuronic/guluronic acid ratio. The hemostasis in liver punch-out injury and bleeding was evaluated using swine. For the study, sodium calcium alginate with different compositions was randomly applied to bleeding sites. Previous hemostatic materials, including cellulose and sodium alginate, were used as a control. We investigated hemostasis at 2 and 5 minutes after application. Results
Each powder size (53–150 μm, 150–250 μm, 53–250 μm) had a similar hemostatic effect. However, the hemostatic rate was significantly higher in sodium calcium alginate than in previous hemostatic materials (P value < .01). A 74.1% calcium substitution rate had the highest hemostasis at 2 and 5 minutes after application (2 minutes: 100%, 5 minutes: 95.2%). Regarding molecular weight, the hemostatic rate was significantly higher in 333,000 than in 50,000 (2 minutes: 95% vs 70%, 5 minutes: 95% vs 70%, P = .038). Moreover, a 1.9 mannuronic/guluronic acid ratio had the highest hemostasis compared with the 0.4 mannuronic/guluronic acid ratio (2 minutes: 58.8% vs 11.8%, 5 minutes: 58.8% vs 0%, P = .033) Conclusion
The composition of sodium calcium alginate with a high hemostatic effect was optimized. This new hemostatic material demonstrated potential usefulness for bleeding during surgery.
科研通智能强力驱动
Strongly Powered by AbleSci AI