适体
纳米载体
纳米医学
纳米技术
DNA折纸
DNA
药物输送
癌症治疗
靶向给药
生物相容性
DNA纳米技术
癌症
材料科学
化学
纳米结构
纳米颗粒
生物
分子生物学
生物化学
遗传学
冶金
作者
Atena Jabbari,Elham Sameiyan,Elnaz Yaghoobi,Mohammad Ramezani,Mona Alibolandi,Khalil Abnous,Seyed Mohammad Taghdisi
标识
DOI:10.1016/j.ijpharm.2023.123448
摘要
Due to the limitations of conventional cancer treatment methods, nanomedicine has appeared as a promising alternative, allowing improved drug targeting and decreased drug toxicity. In the development of cancer nanomedicines, among various nanoparticles (NPs), DNA nanostructures are more attractive because of their precisely controllable size, shape, excellent biocompatibility, programmability, biodegradability, and facile functionalization. Aptamers are introduced as single-stranded RNA or DNA molecules with recognize their corresponding targets. So, incorporating aptamers into DNA nanostructures led to influential vehicles for bioimaging and biosensing as well as targeted cancer therapy. In this review, the recent developments in the application of aptamer-based DNA origami and DNA nanostructures in advanced cancer treatment have been highlighted. Some of the main methods of cancer treatment are classified as chemo-, gene-, photodynamic- and combined therapy. Finally, the opportunities and problems for targeted DNA aptamer-based nanocarriers for medicinal applications have also been discussed.
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