自愈水凝胶
伤口愈合
材料科学
生物相容性
细胞外基质
丹参
血管生成
生物粘附
药物输送
纳米技术
生物医学工程
化学
癌症研究
生物化学
医学
高分子化学
外科
替代医学
中医药
病理
冶金
作者
Huang Xiao-Jing,Tingting Li,Xingyue Jiang,Zhuole Wang,Mingshui Wang,Xia Wu,Ji Li,Junfeng Shi
标识
DOI:10.1021/acsami.3c09219
摘要
Supramolecular natural product gels (NPGs) have emerged as promising biomaterials for scalable and adjustable drug delivery systems. These gels possess biocompatibility, biodegradability, and the ability to mimic the extracellular matrix. Salvianolic acid B (SAB), derived from Salvia miltiorrhiza, a Chinese medicinal plant, exhibits various beneficial properties such as antioxidant, antifibrotic, and angiogenic effects. In our research, we serendipitously discovered that the co-assembly of SAB and a soluble phosphopeptide results in the formation of a robust and adhesive hydrogel termed 1&SAB hydrogel. This hydrogel effectively prolongs the retention time of the therapeutic agents on the skin's wound surface, thereby promoting wound healing. The hydrogel demonstrates antioxidant effects, enhances cell migration, accelerates angiogenesis, and inhibits scar hyperplasia. This innovative gel material offers a simple and efficient approach to managing skin wounds and holds promise for application in complex wound-healing treatments.
科研通智能强力驱动
Strongly Powered by AbleSci AI