孟德尔随机化
观察研究
医学
混淆
遗传关联
连锁不平衡
随机对照试验
疾病
遗传学
遗传变异
等位基因
生物
内科学
单核苷酸多态性
基因型
单倍型
基因
作者
Michael G. Levin,Stephen Burgess
出处
期刊:JAMA Cardiology
[American Medical Association]
日期:2023-11-08
卷期号:9 (1): 79-79
被引量:43
标识
DOI:10.1001/jamacardio.2023.4115
摘要
Mendelian randomization (MR) is a statistical approach that has become increasingly popular in the field of cardiovascular disease research. It offers a way to infer potentially causal relationships between risk factors and outcomes using observational data, which is particularly important in cases where randomized clinical trials are not feasible or ethical. With the growing availability of large genetic data sets, MR has become a powerful and accessible tool for studying the risk factors for cardiovascular disease.
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