表面改性
化学
脱羧
金属
组合化学
有机化学
催化作用
物理化学
作者
Lei Liang,Yuehui Wang,Cheng‐Xing Cui,X.Q. Deng,Songlin Wang,Hai‐Ming Guo,Yingzi Li,Hong‐Ying Niu,Runze Mao
标识
DOI:10.1002/ange.202415131
摘要
Here we report a metal‐ and light‐free decarboxylative functionalization approach enabled by reduced nicotinamide adenine dinucleotide (NADH) analogues. The efficient and operationally simple approach, conducted in 5 minutes from in‐situ preparation of aryliodine (III) dicarboxylates under open‐air and ambient conditions, enables diverse bond formation and exhibits a broad substrate scope of over 70 examples. Late‐stage functionalization of drug molecules and natural products further demonstrates the synthetic utility of this method. Combined experimental and computational studies elucidate the mechanistic pathway. These transformations streamline the synthesis of sp3 carbon‐enriched compounds, adding a new dimension to classical decarboxylative reactions.
科研通智能强力驱动
Strongly Powered by AbleSci AI