苯并吡喃
化学
一氧化氮
脂多糖
IC50型
立体化学
药理学
生物化学
体外
生物
有机化学
内分泌学
作者
Young-Jun Ha,Tae Hyun Lee,Lalita Subedi,Hye Ryeong Kim,Gyuri Moon,Sun Yeou Kim,Chung Sub Kim
出处
期刊:Natural product sciences
[The Korean Society of Pharmacognosy (KAMJE)]
日期:2022-03-31
卷期号:28 (1): 1-5
标识
DOI:10.20307/nps.2022.28.1.1
摘要
Two 2H-1-benzopyran derivatives, methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-5-carboxylate (1) and methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carboxylate (2), including a new compound (1) were isolated from the twigs of Chaenomeles sinensis. Their chemical structures were characterized based on analysis of NMR data including 1H and 13C, COSY, HSQC, and HMBC and HRMS data. The isolated compounds (1 and 2) were assessed for their anti-neuroinflammatory activity by measuring inhibition levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and for their neurotrophic activity by the secretion of nerve growth factor (NGF) in C6 cells. Compounds 1 and 2 exhibited powerful anti-neuroinflammatory effects with IC50 values of 17.14 and 19.30 μM, respectively, without cell toxicity, and also showed moderate effects on the stimulation of NGF secretion levels with 113.15 ± 3.54 and 130.20 ± 8.03%, respectively. The biosynthetic pathway of 1 and 2 was proposed that they would be derived from a protocatechuic acid and an isoprenyl unit.
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