立体中心
化学
对映选择合成
布朗斯特德-洛瑞酸碱理论
催化作用
四级碳
碳原子
有机化学
有机催化
碳纤维
氟
药物化学
组合化学
戒指(化学)
复合材料
材料科学
复合数
作者
Milon M. Sadhu,Sumit K. Ray,Rajshekhar A. Unhale,Vinod K. Singh
摘要
A Brønsted acid-catalyzed asymmetric Mannich-type addition of 1,3-diones to cyclic N-acyl ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl-substituted isoindolinones bearing a quaternary carbon stereocenter were synthesized with excellent yields (up to 98%) and moderate to high enantioselectivities (up to 95% ee), and most of them possess a fluorine atom at the reactive center. Furthermore, the synthetic utility of the protocol has been demonstrated by the debenzoylation of the product.
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