光动力疗法
癌症研究
光敏剂
免疫原性细胞死亡
纳米医学
医学
癌症
癌症治疗
免疫疗法
免疫系统
免疫学
纳米技术
材料科学
内科学
化学
纳米颗粒
有机化学
作者
Jiwoong Choi,In‐Cheol Sun,Hee Sook Hwang,Hong Yeol Yoon,Kwangmeyung Kim
标识
DOI:10.1016/j.addr.2022.114344
摘要
Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Recently, newly designed photodynamic nanomedicines and their combination chemo- or immune checkpoint inhibitor therapy enable the systemic treatment of various metastatic tumors by eliciting antitumor immune responses via immunogenic cell death (ICD). This review introduces recent advances in photodynamic nanomedicines and their applications, focusing on overcoming current limitations. Finally, the challenges and future perspectives of the clinical translation of photodynamic nanomedicines in cancer PDT are discussed.
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