自噬
小胶质细胞
神经炎症
冲程(发动机)
神经科学
缺血性中风
机制(生物学)
医学
疾病
生物信息学
缺血
生物
免疫学
炎症
内科学
细胞凋亡
机械工程
生物化学
哲学
认识论
工程类
作者
Kaichao HU,Yan Gao,Shifeng CHU,Naihong CHEN
标识
DOI:10.1016/j.intimp.2022.108761
摘要
Stroke is a dysfunction caused by acute cerebrovascular disease, which has become the second leading cause of death in the world, resulting in a heavy burden on family and society. As a cellular adaptive mechanism, autophagy denoted a rather pivotal role in the process of ischemic stroke. Recent studies have suggested that autophagy of microglia has an important effect on polarization of phenotype and regulation of neuroinflammation, which implies that regulating autophagy of microglia may be a promising therapeutic strategy for the treatment of ischemic stroke. Therefore, this article explored the effects and signal pathways of microglial autophagy in ischemic stroke, aim to clarify the mechanism of autophagy of stroke, which will provide a reference for development of new targets for the treatment of ischemic stroke.
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