壁细胞
PDGFRB公司
生物
细胞生物学
斑马鱼
血管平滑肌
解剖
再生(生物学)
电池类型
心肌细胞
细胞
平滑肌
内分泌学
遗传学
基因
作者
Elvin Leonard,Ricardo J. Figueroa,Jeroen Bussmann,Nathan D. Lawson,Julio D. Amigo,Arndt F. Siekmann
出处
期刊:Development
[The Company of Biologists]
日期:2022-04-01
卷期号:149 (7)
被引量:9
摘要
ABSTRACT Vascular networks comprise endothelial cells and mural cells, which include pericytes and smooth muscle cells. To elucidate the mechanisms controlling mural cell recruitment during development and tissue regeneration, we studied zebrafish caudal fin arteries. Mural cells colonizing arteries proximal to the body wrapped around them, whereas those in more distal regions extended protrusions along the proximo-distal vascular axis. Both cell populations expressed platelet-derived growth factor receptor β (pdgfrb) and the smooth muscle cell marker myosin heavy chain 11a (myh11a). Most wrapping cells in proximal locations additionally expressed actin alpha2, smooth muscle (acta2). Loss of Pdgfrb signalling specifically decreased mural cell numbers at the vascular front. Using lineage tracing, we demonstrate that precursor cells located in periarterial regions and expressing Pgdfrb can give rise to mural cells. Studying tissue regeneration, we did not find evidence that newly formed mural cells were derived from pre-existing cells. Together, our findings reveal conserved roles for Pdgfrb signalling in development and regeneration, and suggest a limited capacity of mural cells to self-renew or contribute to other cell types during tissue regeneration.
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