卡马西平
医学
三叉神经痛
毒性
彗差(光学)
麻醉
加药
抗惊厥药
情绪稳定器
钠通道阻滞剂
癫痫
药理学
内科学
精神科
钠
钠通道
有机化学
化学
物理
光学
作者
Rachel E. Bridwell,Samuel M. Brown,Sean Clerkin,Sara Birdsong,Brit Long
标识
DOI:10.1016/j.ajem.2022.01.044
摘要
Carbamazepine is a medication used to treat a variety of neurological and psychiatric conditions including seizure disorders, neuropathic pain syndromes, and bipolar disorder. Unfortunately, its pharmacokinetics and side effect profile may lead to significant toxicities due to its sodium channel blockade. In 2019, there were over 1500 cases of isolated carbamazepine toxicity reported to poison centers across the United States. Carbamazepine toxicity may result in vague neurological symptoms in milder cases, but in severe toxicity, it can cause cardiovascular instability, intractable seizures, and coma. In this article, we describe a case of a 40-year-old female who presented to a local emergency department with focal neurological deficits after repeated supratherapeutic dosing of carbamazepine.. This case highlights a key cerebrovascular accident mimic that emergency physicians should consider from acute toxicity that can be seen with carbamazepine in a patient who was taking the medication as prescribed.
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