赫拉
磷酸丝氨酸
蛋白质酪氨酸磷酸酶
磷酸酶
分子生物学
染料木素
酪氨酸
磷酸化
化学
生物
细胞生物学
生物化学
细胞
内分泌学
丝氨酸
出处
期刊:PubMed
日期:1996-03-01
卷期号:38 (3): 607-16
被引量:3
摘要
Incubation of Hela cells in the presence of insulin results in suppression of p53 expression. Treatment of cells with vanadate, an inhibitor of protein tyrosine phosphatase, likewise led to a dramatic reduction in the level of p53 transcript. On the other hand, significant induction of p53 message was demonstrated when Hela cells were exposed to genistein, a protein tyrosine kinase inhibitor. When cells were cultured in the presence of phosphotyrosine, there was a marked decrease in p53 expression. Neither phosphoserine nor phosphothreonine had an effect on p53 expression. Furthermore, simultaneous presence of both insulin and phosphotyrosine did not result in a greater suppression of the p53 message than when either of the agents was acting singly.
科研通智能强力驱动
Strongly Powered by AbleSci AI