| 标题 |
 Histone lactylation drives CD8+ T cell metabolism and function 组蛋白乳酸化驱动CD8+T细胞代谢和功能
相关领域
CD8型
细胞毒性T细胞
细胞生物学
T细胞
生物
效应器
组蛋白
表观遗传学
表型
功能（生物学）
免疫系统
基因
遗传学
体外
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| 网址 | |
| DOI |
提醒：求助人提供的doi与AI识别不一致
10.1101/2023.08.25.554830
Doi
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| 其它 |
Abstract The activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+ T cell activation and function is not known. Here, we show the enrichment of H3K18 lactylation (H3K18la) and H3K9 lactylation (H3K9la) in human and mouse CD8+ T cells, which act as transcription initiators of key genes regulating CD8+ T cell function. Further, we note distinct patterns of H3K18la and H3K9la in CD8+ T cell subsets linked to their specific metabolic profiles. Additionally, we find that modulation of H3K18la and H3K9la by targeting metabolic and epigenetic pathways influence CD8+ T cell effector function, including antitumor immunity, in preclinical models. Overall, our study uncovers the potential roles of H3K18la and H3K9la in CD8+ T cells. |
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