| 标题 |
Bioisosteric-replacement-driven optimization of 4-methoxynaphthalene-N-acylhydrazones with anti-Paracoccidioides activity
生物等排置换驱动的4-甲氧基萘-N-酰基腙抗副枕骨类化合物活性的优化
|
| 网址 |
求助人暂未提供
|
| DOI |
暂未提供，该求助的时间将会延长，查看原因？
|
| 其它 | Paracoccidioidomycosis (PCM) is a serious system fungal infection that causes significant death and suffering, particularly in Latin America. The treatment of PCM is limited by a few pharmacological options that require long-term administration protocols. Considering the few classes of drugs available for the treatment of PCM and the long time of the treatment, developing new anti-PCM compounds is relevant. With the purpose to develop new 4-methoxynaphthalene-N-acylhydrazone bioisosteres with anti-Paracoccidioides activity, a series of 4-methoxynaphthalene-N-acylhydrazones, which had already been tested against P. brasiliensis, was used to develop shape-based models. The models underwent statistical validation and were used to filter a library of compounds, which were ranked using scoring functions. Molecular docking analysis was used to select 6 compounds that were synthesized and |
| 求助人 | |
| 下载 |
穆紫
凤凰
美好乐松
JY
寻道图强
结实的寄柔
可爱的函函
账户已注销
科目三
eternity136
陈军
一一
斯文败类
只谈风月
毛豆爸爸
Singularity
小蘑菇
华仔
畅快的毛衣
CipherSage
皖公网安备34019202002308
