免疫球蛋白D
B-1电池
幼稚B细胞
CD40
体细胞突变
CD154
B细胞
生发中心
B细胞受体
生物
等离子体电池
记忆B细胞
抗体
细胞生物学
抗原
免疫学
分子生物学
细胞毒性T细胞
体外
遗传学
出处
期刊:PubMed
日期:2000-04-01
卷期号:15 (2): 573-6
被引量:31
摘要
Following antigen activation in germinal centers, B cells develop into memory B cells or plasma cells. Triggering via B-cell immunoglobulin receptors by antigens, cytokines and direct cell-to-cell contact by B and T cells plays an important role in the B cell differentiation into memory or plasma cells. Adult human peripheral blood B cells are separated into three subtypes by the expression of IgD and CD27, which belong to the tumor necrosis factor receptor (TNFR) family: IgD+ CD27- naive B cells, IgD+ CD27+ and IgD- CD27+ B cells. CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells. We review observations on subpopulations and differentiation of mature B-cells by T/B cell interaction via CD27/CD70 as compared with CD40/CD154 interaction, and discuss about memory B cells.
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