再髓鞘化
多发性硬化
神经科学
炎症
疾病
髓鞘
轴突
再生(生物学)
实验性自身免疫性脑脊髓炎
医学
生物
免疫学
中枢神经系统
细胞生物学
病理
作者
Robin J.M. Franklin,Mikael Simons
出处
期刊:Neuron
[Elsevier]
日期:2022-10-12
卷期号:110 (21): 3549-3565
被引量:62
标识
DOI:10.1016/j.neuron.2022.09.023
摘要
Remyelination, the myelin regenerative response that follows demyelination, restores saltatory conduction and function and sustains axon health. Its declining efficiency with disease progression in the chronic autoimmune disease multiple sclerosis (MS) contributes to the currently untreatable progressive phase of the disease. Although some of the bona fide myelin regenerative medicine clinical trials have succeeded in demonstrating proof-of-principle, none of these compounds have yet proceeded toward approval. There therefore remains a need to increase our understanding of the fundamental biology of remyelination so that existing targets can be refined and new ones discovered. Here, we review the role of inflammation, in particular innate immunity, in remyelination, describing its many and complex facets and discussing how our evolving understanding can be harnessed to translational goals.
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