生殖系
生物
干细胞
生殖细胞
细胞生物学
遗传学
发育生物学
抑制因子
基因
基因表达
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2004-03-26
卷期号:303 (5666): 2016-2019
被引量:224
标识
DOI:10.1126/science.1093983
摘要
Despite much progress in understanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-autonomous gene regulation controls this process. In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to produce daughter GSCs and cystoblasts, the latter of which develop into germline cysts. Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts. Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs.
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