卡拉胶
余甘子
易碎性
药理学
传统医学
水肿
化学
医学
药品
外科
首过效应
作者
Amulyaratna Behera,Himansu Bhusan Samal,Dinesh Kumar Sharma,Satish Kanhar,Atul Kadam,Prachi Khamkar,Suchismeeta Behera
出处
期刊:Journal of pharmaceutical research international
[Sciencedomain International]
日期:2021-12-11
卷期号:: 155-167
标识
DOI:10.9734/jpri/2021/v33i54b33776
摘要
Aim: In the current investigation, tablet dosage form of hydroalcohol extract of leaves of P. emblica was developed and evaluated foranti-inflammatory activities.
Methodology: Hydroalcohol extract of leaves of P. Emblica (HPE) was prepared and formulated tablet dosage form. The mechanical properties e.g. hardness, friability, disintegration, and dissolution of tablet were evaluated. Anti-inflammatory activities of HPE (150 mg/kg) and HPE (650 mg) tablets were performed in carrageenan induced hind paw edema in wistar rats.
Results: The anti-inflammatory activity was found to be significant in carrageenan inducedpaw edema. HPE (150 mg/kg) and HPE tablets (650 mg) were significantly (p < 0.05) reduced the carrageenan induced paw edemaby 66.41% and 69.43% respectively as compared to carragenan control. The % inhibition of standard drug (dichlorofenac sodium) was recorded to be 70.18% after 5 h.
Conclusion: The study standardised the development of HPE tablet and its anti-inflammatory effect.
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