Myoclonus as a Manifestation of Reflex Seizures

Summary: Myoclonus is a motor symptom commonly associated with reflex seizures in people with idiopathic generalized epilepsies. The most frequently observed triggers of myoclonus are related to visual stimuli, including flashing lights or patterns; nonetheless, myoclonus can also be activated by movement, speech or reading, calculations, and praxis. Reflex myoclonic seizures may be the hallmark of a reflex epilepsy, but it may lead to the diagnosis of generalized epilepsy syndromes. In the setting of idiopathic generalized epilepsies, reflex myoclonus can persist despite optimal medical therapies and may be a marker for active, even medically intractable, epilepsy. In this article, the clinical significance, diagnosis, and treatment of myoclonus, associated with visual stimulation, movement, and praxis, will be reviewed.