Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study

医学 可视模拟标度 活检 置信区间 优势比 医学诊断 接收机工作特性 内科学 放射科 外科
作者
Jan Nico Bouwes Bavinck,Catherine A. Harwood,Roel E. Genders,Hermina C. Wisgerhof,Elsemieke I. Plasmeijer,L. Mitchell,Edit Olasz,Daniel D. Mosel,Madeline S. Pokorney,Andreas Serra,Laurence Feldmeyer,Katrin Baumann Conzett,Stefano Piaserico,Anna Belloni Fortina,Katharina Jähn,Alexandra Geusau,Marinel Gerritsen,Deniz Seçkin,A. Tülin Güleç,Petra Cetkovská,Jan Říčař,Beata Imko‐Walczuk,Charlotte M. Proby,Günther F.L. Hofbauer
出处
期刊:American Journal of Transplantation [Wiley]
卷期号:14 (3): 668-676 被引量:17
标识
DOI:10.1111/ajt.12587
摘要

Organ transplant recipients (OTR) are at high risk for cutaneous squamous cell carcinomas (SCC). We aimed to define clinically meaningful patient-reported warning signals predicting the presence of invasive SCC. Patient-reported signs and symptoms of 812 consecutively biopsied skin lesions from 410 OTR were determined by questionnaire and physical examination and related to the subsequent biopsy-proven diagnoses. Receiver-operating characteristic (ROC) curve analyses were used as a measure of distinction between the predictive values of patient-reported warning signals and the occurrence of SCC. Pain was an independent predictive patient-reported warning signal for a biopsy-proven invasive SCC. The odds ratio from the fully adjusted model predicting SCC was 4.4 (95% confidence interval: 2.4–8.2). Higher scores on the visual analog scale (VAS) for pain were associated with a greater likelihood for the presence of SCC compared to none or mild pain. The for scores on the VAS from 1 to 3, 4 to 6 and 7 to 10 were 4.9 (2.2–10.5), 2.3 (0.96–5.5) and 16.5 (3.6–75.8), respectively. Pain is the most powerful patient-reported warning signal for invasive cutaneous SCC in OTR. Empowerment of patients by education could accelerate diagnosis and treatment of cutaneous SCC.

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