Synthesis of a New Series of N‐Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases

The reaction of isatin 1 with benzaldehyde and a sec ‐amine or the appropriate aldimine afforded the N ‐Mannich bases 2 – 3 and the bis‐base 4 . Treatment of 1 with glutaric dialdehyde and morpholine gave the bis‐base 5 . Mannich reaction of the Schiff bases 6a – f derived from 1 , led to the new Mannich bases and bis‐bases 7 – 9 . The use of N ‐methyl‐ D ‐glucamine as the amine component in the Mannich reaction with 6b – f led to the polyhydroxy Mannich bases 11 – 13 .