对乙酰氨基酚
丙二醛
化学
肝损伤
氧化应激
胆红素
类黄酮
谷胱甘肽过氧化物酶
谷胱甘肽
过氧化氢酶
抗氧化剂
药理学
生物化学
内科学
医学
酶
作者
Afolabi C. Akinmoladun,Mary Tolulope Olaleye,Kayode Komolafe,Abayomi O. Adetuyi,Afolabi Akintunde Akindahunsi
出处
期刊:Journal of basic and clinical physiology and pharmacology
[De Gruyter]
日期:2015-03-26
卷期号:26 (6): 555-562
被引量:14
标识
DOI:10.1515/jbcpp-2014-0095
摘要
Novel hepatoprotectives are needed to address the increasing cases of liver problems worldwide. Pterocarpus erinaceus Poir (Fabaceae) ethanol stem bark extract (PE) and its constituent flavonoid, homopterocarpin (HP), were investigated for their protective property in acetaminophen-induced oxidative stress and liver damage.Adult male albino rats were divided into nine groups. Seven groups were pretreated with PE (50-, 100-, and 150 mg/kg), HP (25-, 50-, and 75 mg/kg) or silymarin (25 mg/kg), respectively, once daily for 5 consecutive days and then administered acetaminophen (2 g/kg) on the 5th day. The control and acetaminophen-intoxicated groups received normal saline throughout the experimental period, with the latter group additionally receiving 2 g/kg acetaminophen on the 5th day. Administrations were performed po.In the acetaminophen-intoxicated group, there were significant increases (p<0.05) in serum activities of alanine aminotransferase (31.72±3.3 vs. 22.1±1.2 U/I), aspartate aminotransferase (185.1±10.1 vs. 103.83±13.3 U/I), bilirubin level and hepatic malondialdehyde (2.32±0.3 vs. 1.42±0.1 units/mg protein), accompanied with significant decreases (p<0.05) in hepatic reduced glutathione level (0.10±0.01 vs. 0.23±0.03 units/mg protein) and glutathione peroxidase activity (2.51±0.2 vs. 3.25±0.2 μmol H2O2 consumed/min/mg protein) compared with the control.PE and HP ameliorated most of the observed biochemical alterations with HP appearing to show more potency. The results suggest that the flavonoid, homopterocarpin contributes to the hepatoprotective and antioxidant potentials of P. erinaceus extract.
科研通智能强力驱动
Strongly Powered by AbleSci AI