血管内皮生长因子
胎盘生长因子
生长因子
内分泌学
内科学
血管内皮生长因子C
医学
单核细胞
血小板源性生长因子受体
血管内皮生长因子A
糖尿病性视网膜病变
激酶插入结构域受体
血管内皮生长因子B
受体
糖尿病
血管内皮生长因子受体
作者
Hidetaka Noma,Tatsuya Mimura,Kanako Yasuda,Ryosuke Motohashi,Osamu Kotake,Masahiko Shimura
出处
期刊:Ophthalmologica
[S. Karger AG]
日期:2017-01-01
卷期号:238 (1-2): 81-88
被引量:45
摘要
Aqueous levels of soluble vascular endothelial growth factor receptor (sVEGFR) and inflammatory factors were measured in 35 patients (37 eyes) with diabetic macular edema (DME)<b> </b>receiving anti-vascular endothelial growth factor (VEGF) therapy. Aqueous levels of growth factors (VEGF, placental growth factor [PlGF], and platelet-derived growth factor AA [PDGF-AA]), sVEGFR-1 and -2, soluble intercellular adhesion molecule 1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, -8, -12, and -13, and interferon-inducible 10-kDa protein (IP-10) were significantly higher in the DME group than in the nondiabetic control group. The sVEGFR-2 level was significantly correlated with the neurosensory retinal thickness, as well as with the levels of growth factors (VEGF and PDGF-AA) and inflammatory factors (MCP-1, IL-6, and IL-8). Three growth factors (VEGF, PlGF, and PDGF-AA) were also significantly correlated with each other, as were sVEGFR-1 or -2 and the inflammatory factors (MCP-1, IL-6, IL-8, and IP-10). These findings suggest that sVEGFRs and growth/inflammatory factors have an important role in DME.
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