表面改性
石墨烯
生物相容性
氧化物
表征(材料科学)
材料科学
还原(数学)
纳米技术
半胱氨酸
化学
有机化学
数学
物理化学
几何学
酶
冶金
作者
Abdelsattar O.E. Abdelhalim,Vladimir V. Sharoyko,Anatolii A. Meshcheriakov,Sofia D. Martynova,Sergei V. Ageev,Gleb O. Iurev,Hadeer Al Mulla,Andrey V. Petrov,Irina L. Solovtsova,Lubov V. Vasina,Igor V. Murin,Konstantin N. Semenov
标识
DOI:10.1016/j.nano.2020.102284
摘要
This article presents data on the synthesis, identification, computer simulation and biocompatibility of graphene oxide (GO) functionalized with L-cysteine (GFC). It was determined that GO reacts with L-cysteine in two different ways: in an alkaline medium, L-cysteine reduces functional groups on the surface and at the boundaries of GO; with heating and the use of thionyl chloride, L-cysteine covalently attaches to GO through carboxylic groups only at the boundaries. The identification of GO, reduced graphene oxide and GFC was performed using various physicochemical methods, including infrared spectroscopy, Raman spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, thermogravimetric analysis, scanning electron microscopy and high-resolution transmission electron microscopy. Biocompatibility experiments included erythrocyte hemolysis, platelet aggregation, photodynamic and antiradical activity, binding to human serum albumin, and geno- and cytotoxicity studies. Applying density functional theory and molecular dynamics allowed us to obtain the structural and dynamic characteristics of a GFC-water binary system.
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