光动力疗法
谷胱甘肽
化学
光毒性
角质层
肿瘤缺氧
姜黄素
光敏剂
癌症研究
药理学
医学
放射治疗
生物化学
病理
体外
光化学
酶
有机化学
内科学
作者
Yashi Li,Gang He,Lian‐Hua Fu,Muhammad Rizwan Younis,Tingchao He,Yunzhi Chen,Jing Lin,Zhiming Li,Peng Huang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-09-27
卷期号:16 (10): 17298-17312
被引量:46
标识
DOI:10.1021/acsnano.2c08098
摘要
Photodynamic therapy (PDT) has attained extensive attention as a noninvasive tumor treatment modality. However, the hypoxia in solid tumors, skin phototoxicity of "always on" photosensitizers (PSs), and abundant supply of glutathione (GSH) in cancer cells severely hampered the clinical applications of PDT. Herein, a self-oxygenation nanoplatform (denoted as CZCH) with GSH depletion ability was encapsulated into the hyaluronic acid microneedle patch (MN-CZCH) to simultaneously improve the biosafety and therapeutic efficacy of PDT. The Cu2+-doped porous zeolitic imidazolate framework incorporated with catalase (CAT) is capable of efficiently loading PS 2-(1-hexyloxyethyl)-2-divinylpyropheophorbic-a (HPPH). The CZCH intermingled MN patch (MN-CZCH) could effectively penetrate the stratum corneum, topically transport HPPH to the target tumor site, achieve a long tumor retention time, and enhance the efficacy of PDT via the simultaneously synergistic effect of CAT-catalyzed self-supplying O2 and Cu2+-mediated GSH depletion. Using traceable fluorescence (FL) imaging of the released HPPH from CZCH, the FL imaging-guided repeatable PDT can be achieved for enhanced antitumor efficacy. As a result, the MN-CZCH patch exhibited excellent therapeutic efficacy against melanoma with minimal toxicity, which has promising potential for cancer theranostics.
科研通智能强力驱动
Strongly Powered by AbleSci AI