Immunoregulation of bovine lactoferrin together with osteopontin promotes immune system development and maturation

乳铁蛋白 骨桥蛋白 免疫系统 化学 牛乳 细胞生物学 免疫学 生物 生物化学
作者
Chuangang Li,Yao Lu,Jian Wang,Biao Liu,Ignatius Man‐Yau Szeto,Wen Zhang,Ran Bi,Sufang Duan,Rui Quan,Xuemin Wang,Yixuan Li,Wei Xiong,Jiazeng Sun,Yanan Sun
出处
期刊:Food & Function [Royal Society of Chemistry]
卷期号:15 (2): 866-880 被引量:1
标识
DOI:10.1039/d3fo03515h
摘要

The immune system of infants is partly weak and immature, and supplementation of infant formula can be of vital importance to boost the development of the immune system. Lactoferrin (LF) and osteopontin (OPN) are essential proteins in human milk with immunoregulation function. An increasing number of studies indicate that proteins have interactions with each other in milk, and our previous study found that a ratio of LF : OPN at 1 : 5 (w/w, denoted as LOP) had a synergistic effect on intestinal barrier protection. It remains unknown whether LOP can also exert a stronger effect on immunoregulation. Hence, we used an in vitro model of LPS-induced macrophage inflammation and in vivo models of LPS-induced intestinal inflammation and early life development. We showed that LOP increased the secretion of the granulocyte-macrophage colony-stimulating factor (132%), stem cell factor (167%) and interleukin-3 (176%) in bone marrow cells, as well as thymosin (155%) and interleukin-10 (161%) in the thymus, more than LF or OPN alone during development, and inhibited changes in immune cells and cytokines during the LPS challenge. In addition, analysis of the components of digested proteins in vitro revealed that differentially expressed peptides may provide immunoregulation. Lastly, LOP increased the abundance of Rikenellaceae, Muribaculum, Faecalibaculum, and Elisenbergiella in the cecum content. These results imply that LOP is a potential immunomodifier for infants and offers a new theoretical basis for infant formula innovation.
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