血栓
血栓形成
葡萄激酶
水蛭素
医学
心脏病学
生物
内科学
凝血酶
细菌
血小板
遗传学
金黄色葡萄球菌
作者
Zhaoqing Cong,Yangyang Li,Leiming Xie,Qiwei Chen,Menghuan Tang,Phonpilas Thongpon,Yanxiao Jiao,Song Wu
出处
期刊:Small
[Wiley]
日期:2024-05-27
被引量:1
标识
DOI:10.1002/smll.202400847
摘要
Abstract In the realm of thrombosis treatment, bioengineered outer membrane vesicles (OMVs) offer a novel and promising approach, as they have rich content of bacterial‐derived components. This study centers on OMVs derived from Escherichia coli BL21 cells, innovatively engineered to encapsulate the staphylokinase‐hirudin fusion protein (SFH). SFH synergizes the properties of staphylokinase (SAK) and hirudin (HV) to enhance thrombolytic efficiency while reducing the risks associated with re‐embolization and bleeding. Building on this foundation, this study introduces two cutting‐edge microrobotic platforms: SFH‐OMV@H for venous thromboembolism (VTE) treatment, and SFH‐OMV@MΦ, designed specifically for cerebral venous sinus thrombosis (CVST) therapy. These platforms have demonstrated significant efficacy in dissolving thrombi, with SFH‐OMV@H showcasing precise vascular navigation and SFH‐OMV@MΦ effectively targeting cerebral thrombi. The study shows that the integration of these bioengineered OMVs and microrobotic systems marks a significant advancement in thrombosis treatment, underlining their potential to revolutionize personalized medical approaches to complex health conditions.
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