Role of the Notch1 signaling pathway in ischemic heart disease (Review)

Ischemic heart disease (IHD) is a prevalent cardiovascular disease characterized by the formation, progression and rupture of atherosclerotic plaque. The Notch signaling pathway is a key mechanism facilitating intercellular coordination. An increasing number of studies have revealed the significance of Notch signaling, particularly as regards Notch1. Of note, the existence of aberrant Notch1 signaling in IHD is universal, suggesting clinical significance. Thus, the present review summarizes the implications of Notch1 signaling in endothelial cells, vascular smooth muscle cells and macrophages in association with the development of IHD. The present review also examined the effects of Notch1 signaling on various remodeling stages of IHD consisting of reendothelialization, neovascularization, and myocardial fibrosis. Moreover, the participation of Notch1 signaling in conventional reperfusion treatments and cardiac regeneration therapies is discussed. On the whole, the present review aims to outline Notch1 signaling as a novel target which may be used to enhance the treatment efficacy for patients with IHD.