微气泡
马来酰亚胺
两亲性
材料科学
对比度(视觉)
超声波
纳米技术
化学工程
化学
高分子化学
复合材料
聚合物
计算机科学
共聚物
人工智能
工程类
物理
声学
作者
Jie Cen,Xianjun Ye,Xiao Liu,Wenhao Pan,Lei Zhang,Guoying Zhang,Nianan He,Aizong Shen,Jinming Hu,Shiyong Liu
标识
DOI:10.1002/anie.202209610
摘要
Abstract Gas‐filled microbubbles (MBs) have been clinically used as ultrasound (US) contrast agents for disease diagnosis and treatment. However, it remains a great challenge to resolve the dilemma of stability and contrast enhancement of MBs. Herein, amphiphilic copolypeptides bearing fluorinated blocks are synthesized to stabilize perfluorocarbon (PFC)‐filled MBs, exhibiting unique stability under both long‐term storage and US imaging conditions. The fluorinated inner layer reduces the internal Laplace pressure and greatly improves the stability of MBs, which can be further reinforced by crosslinking of the dipropargyl‐containing middle blocks. To overcome the suppressed nonlinear oscillation of polymer shells, maleimide groups are introduced onto the surface of MBs, enabling in situ reaction with plasma proteins to enhance second harmonic signals without compromising the stability of MBs, conferring better US imaging performance than that of SonoVue TM MBs.
科研通智能强力驱动
Strongly Powered by AbleSci AI