长时程增强
神经科学
刺激(心理学)
创伤性脑损伤
细胞内
心理学
医学
生物
细胞生物学
内科学
精神科
受体
心理治疗师
作者
Tasnim Shireen,Frederick Sachs,Susan Z. Hua
出处
期刊:Brain Research
[Elsevier]
日期:2022-12-01
卷期号:1796: 148076-148076
被引量:1
标识
DOI:10.1016/j.brainres.2022.148076
摘要
Traumatic brain injury (TBI) is a major risk factor for development of neurodegenerative disorders later in life. Short, repetitive, mechanical impacts can lead to pathology that appears days or months later. The cells have a physical "memory" of mechanical events. The origin of this memory is not known. To examine the properties of this memory, we used a microfluidic chip to apply programmed fluid shear pulses to adherent adult rat astrocytes. These caused a transient rise in intracellular Ca2+. In response to repeated stimuli, 6 to 24 hrs apart, the Ca2+ response increased. This effect lasted longer than 24 hrs. The Ca2+ responses were more sensitive to the number of repetitions than to the rest time between stimuli. We found that inhibiting the Ca2+ influx during conditioning stimulus did not eliminate the stress potentiation, suggesting that mechanical deformation during the primary injury is accountable for the later response. The mechanical mechanism that triggers this long term "memory" may act by plastic deformation of the cytoskeleton.
科研通智能强力驱动
Strongly Powered by AbleSci AI