癌症
癌症研究
活性氧
一氧化氮
氧化应激
转移
癌细胞
化学
免疫系统
医学
免疫抑制
药理学
免疫学
内科学
生物化学
作者
Wenchang Zhou,Jie Zhang,Wankun Chen,Changhong Miao
标识
DOI:10.1007/s00432-024-05685-7
摘要
Abstract Gas signaling molecules, including carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H 2 S), have been shown to have cancer therapeutic potential, pointing to a new direction for cancer treatment. In recent years, a series of studies have confirmed that hydrogen (H 2 ), a weakly reductive gas, also has therapeutic effects on various cancers and can mitigate oxidative stress caused by radiation and chemotherapy, reducing tissue damage and immunosuppression to improve prognosis. Meanwhile, H 2 also has immunomodulatory effects, inhibiting T cell exhaustion and enhancing T cell anti-tumor function. It is worth noting that human intestinal flora can produce large amounts of H 2 daily, which becomes a natural barrier to maintaining the body’s resistance to diseases such as tumors. Although the potential anti-tumor mechanisms of H 2 are still to be investigated, previous studies have shown that H 2 can selectively scavenge highly toxic reactive oxygen species (ROS) and inhibit various ROS-dependent signaling pathways in cancer cells, thus inhibiting cancer cell proliferation and metastasis. The ROS scavenging ability of H 2 may also be the underlying mechanism of its immunomodulatory function. In this paper, we review the significance of H 2 produced by intestinal flora on the immune homeostasis of the body, the role of H 2 in cancer therapy and the underlying mechanisms, and the specific application of H 2 to provide new ideas for the comprehensive treatment of cancer patients.
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