卵清蛋白
双金属片
化学
单宁酸
细胞毒性
光热治疗
光动力疗法
免疫
免疫系统
CD8型
癌症研究
细胞生物学
材料科学
免疫学
纳米技术
生物
生物化学
催化作用
体外
有机化学
作者
Xin Sun,Shiqing Zhang,Qianzhe Li,Mengyu Yang,Xiaonan Qiu,Beibei Yu,Cuixiu Wu,Zhaoliang Su,F. Du,Miaomiao Zhang
标识
DOI:10.1016/j.jcis.2023.03.204
摘要
Phototherapy can trigger immunogenic cell death of tumors in situ, whereas it is virtually impossible to eradicate the tumor due to the intrinsic resistance and inefficient anti-tumor immunity. To overcome these limitations, novel bimetallic infinite coordination nanopolymers (TA-Fe/Mn-OVA@MB NPs) were synthesized using model antigen ovalbumin (OVA) as a template to assemble tannic acid (TA) and bi-metal, supplemented with methylene blue (MB) surface absorption. The formulated TA-Fe/Mn-OVA@MB NPs possess excellent photothermal and photodynamic therapy (PTT/PDT) performance, which is adequate to destroy tumor cells by physical and chemical attack. Especially, these TA-Fe/Mn-OVA@MB NPs are capability of promoting the dendritic cells (DCs) maturation and antigen presentation via manganese-mediated cGAS-STING pathway activation, finally activating cytotoxicity T lymphocyte and promoting memory T lymphocyte differentiation in the peripheral lymphoid organs. In conclusion, this research offers a versatile metal-polyphenol nanoplatform to integrate functional metals and therapeutic molecule for topical phototherapy and robust anti-tumor immune activation.
科研通智能强力驱动
Strongly Powered by AbleSci AI