神经影像学
中央前回
神经科学
楔前
心理学
神经功能成像
背外侧前额叶皮质
医学
功能磁共振成像
扣带回前部
前额叶皮质
磁共振成像
认知
放射科
作者
Yu Tang,Maohua Wang,Ting Zheng,Yan Xiao,Song Wang,Fugang Han,Guangxiang Chen
出处
期刊:Brain Research
[Elsevier]
日期:2020-12-20
卷期号:1752: 147219-147219
被引量:17
标识
DOI:10.1016/j.brainres.2020.147219
摘要
In recent decades, an increasing number of neuroimaging studies utilizing magnetic resonance imaging (MRI) have explored the differential effects of postherpetic neuralgia (PHN) on brain structure and function. We systematically reviewed and integrated the findings from relevant neuroimaging studies in PHN patients. A total of 15 studies with 16 datasets were ultimately included in the present study, which were categorized by the different neuroimaging modalities. The results revealed that PHN was closely associated with structural/microstructural and functional abnormalities of the brain mainly located in the 'pain matrix', including the thalamus, insula, parahippocampus, amygdala, dorsolateral prefrontal cortex, precentral gyrus and inferior parietal lobe, as well as other regions, such as the precuneus, lentiform nucleus and brainstem. Furthermore, a disruption of multiple networks, including the default-mode network, salience network and limbic system, may contribute to the neurophysiological mechanisms underlying PHN. The findings indicate that the cerebral abnormalities of PHN were not restricted to the pain matrix but extended to other regions, profoundly affecting the regulation and moderation of pain processing in PHN. Future prospective and longitudinal neuroimaging studies with larger samples will elucidate the progressive trajectory of neural changes in the pathophysiological process of PHN.
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